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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 6
BKCSDE 33(6)
June 20, 2012 

 
Title
Ailanthoidol Derivatives and their Anti-inflammatory Effects
Author
Na Li Lee, Jae Jun Lee, Jin-Kyung Kim, Jong-Gab Jun*
Keywords
Ailanthoidol, 2-Arylbenzo[b]furan, Anti-inflammatory, Nitric oxide, Iodine-induced cyclization
Abstract
Ailanthoidol showed a strong anti-inflammatory effect in a previous result. Ailanthoidol derivatives were prepared for the anti-inflammatory test using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared ailanthoidol derivatives were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that some ailanthoidol derivatives inhibited significantly the production of inflammatory mediator nitric oxide.
Page
1907 - 1912
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