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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 9
BKCSDE 33(9)
September 20, 2012 

Synthesis of Small Molecule-Peptide Conjugates as Potential Whitening Agents
Hye-Suk Lee, Kyong-Hoon Shin, Geun-Seok Ryu, Gyeong-Yup Chi, In-Shik Cho, Han-Young Kim*
Peptide, ASP, Tyrosinase, MC1R, Whitening agent
Small molecule conjugated peptides were prepared by solid-phase synthesis as potential novel whitening agents, and their melanogenesis inhibitory activities were investigated. The conjugated small molecules were well-known materials as tyrosinase inhibitors, and peptides were selected from the sequences that are known to antagonize melanocortin receptor 1 (MC1R). Most of small molecules-peptide conjugates showed superior melanin inhibition activity to kojic acid and arbutin. Among these, almost all compounds have -AR- sequence. From this study, we concluded that the small molecule conjugated peptides containing -AR- sequence have melanogenesis inhibitory activities and have potential to be used as novel whitening agents.
3004 - 3008
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