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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 11
BKCSDE 33(11)
November 20, 2012 

Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line
Hye Jung Cho, Mohammed I. El-Gamal, Chang-Hyun Oh, So Ha Lee, Garam Kim, Jun Hee Hong, Hong Seok Choi, Kyung Ho Yoo*
A375P, Aminoisoquinoline, Anticancer, Diarylurea, Melanoma
A series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with IC50 value of 0.41 μM.
3635 - 3639
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