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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 11
BKCSDE 33(11)
November 20, 2012 

The First Report on Chemoselective Biguanide-Catalyzed Henry Reaction under Neat Conditions
Abdolhamid Alizadeh*, Mohammad M. Khodaei*, Gisya Abdi, Davood Kordestani
Organosuper-base catalysts, Henry reaction, Nitroaldol reaction, Biguanides, Metformin
An efficient synthetic method for direct Henry reaction catalyzed by a biguanide; namely metformin, as an organosuper-base, between a variety of aromatic and aliphatic aldehydes and nitromethane under neat conditions has been developed. Convenient procedure for removal of the catalyst, chemoselective acquiring of β-nitroalcohols as predominant products, as far as possible short reaction time with excellent conversions are advantages of the developed protocol.
3640 - 3644
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