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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 11
BKCSDE 33(11)
November 20, 2012 

Four-Component Preparation of Disubstituted 1,3,4-Oxadiazoles from (N-isocyanimino)triphenylphosphorane, Phenylacetylenecarboxylic Acid, Biacetyl and Primary Amines
Ali Ramazani*, Behnaz Abdian, Fatemeh Zeinali Nasrabadi, Nahid Shajari, Zahra Ranjdoost
(N-Isocyanimino)triphenylphosphorane, Biacetyl, Phenylacetylenecarboxylic acid, Primary amine, 1,3,4-Oxadiazole
A simple method has been developed for four-component synthesis of disubstituted 1,3,4-oxadiazoles using (N-isocyanimino)triphenylphosphorane, a primary amine, a carboxylic acid and biacetyl in CH2Cl2 by the Ugi- 4CR/aza-Wittig sequence at room temperature in excellent yields.
3701 - 3705
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