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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 34, Number 3
BKCSDE 34(3)
March 20, 2013 

New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities
Xue-Mei Gao, Yun-Qi Li, Li-Dan Shu, Yan-Qiong Shen, Li-Ying Yang, Liu-Meng Yang, Zheng Yong-Tang, Han-Dong Sun, Wei-Lie Xiao*, Qiu-Fen Hu*
Schisandra wilsoniana, Nortriterpenoid, Anti-HIV-1 activity, Cytotoxicity
Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV- 1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 μg/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 μM, respectively.
827 - 830
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