Current time in Korea 08:49 Oct 17 (Tue) Year 2017 KCS KCS Publications
KCS Publications
My Journal Log In Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 34, Number 5
BKCSDE 34(5)
May 20, 2013 

 
Title
Synthesis of Ergosterol and 5,6-Dihydroergosterol Glycosides and Their Inhibitory Activities on Lipopolysaccharide-Induced Nitric Oxide Production
Author
HoonGyu Park, Tae Hoon Lee, Fei Chang, Hyun Ji Kwon, Jiyoung Kim, Hakwon Kim*
Keywords
Glycosyl ergosterol, Glycosyl 5,6-dihydroergosterol, Glycosylation, Inhibitory activity, NO production
Abstract
We have synthesized several glycosyl ergosterols and 5,6-dihydroergosterols (DHE) and examined their effects on production of nitric oxide (NO) and iNOS protein expression in LPS-treated RAW264.7 macrophage cells. Our results showed that DHE derivatives inhibited production of NO and iNOS protein expression more strongly than ergosterol derivative. Especially, DHE-Glc exhibited most potent inhibitory activity without cytotoxicity up to the concentration of 100 μM.
Page
1339 - 1344
Full Text
PDF