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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 34, Number 8
BKCSDE 34(8)
August 20, 2013 

 
Title
Synthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives
Author
Young Sun Shim, Hyun Sook Hwang, Ghilsoo Nam*, Kyung Il Choi*
Keywords
Thiourea, Vinyl sulfoxide, Nrf2 activator, Parkinson’s disease, Oxidative stress
Abstract
Thiourea and vinyl sulfoxide derivatives were designed based on the structures of sulforaphane and gallic acid, prepared and tested for HO-1 inducing activity as a measure of Nrf2 activation, and inhibitory effect on NO production as a measure of anti-inflammatory activity. Both series of compounds showed moderate activity on HO-1 induction, and no inhibitory effect on NO production. Interestingly the thiourea compound 6d showed better HO-1 induction (71% SFN) than the corresponding isothiocyanate compound 6a (55% SFN). Overall, it seemed that more efficient electrophile is needed to get more effective Nrf2 activator.
Page
2317 - 2320
Full Text
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