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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 34, Number 9
BKCSDE 34(9)
September 20, 2013 

 
Title
N-Phenyl-3-Pyridin-2-yl Imino Derivatives as Vascular Smooth Muscle Relaxants: Potential Phosphodiesterase V Inhibitors
Author
Prafulla Choudhari*, Manish Bhatia, Neela Bhatia
Keywords
Goat aorta, Binding pocket, Phosphodiesterase V, Pharmacophore
Abstract
The present communication deals with development of ten novel N-Phenyl-3-Pyridin-2-yl imino derivatives as vascular smooth muscle relaxants. The derivatives were prepared and optimized using pocket modelling and pharmacophore modelling. The 4 hydroxy substituted derivatives are showed potent activity comparable to the sildenafil.
Page
2707 - 2710
Full Text
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