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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 34, Number 12
BKCSDE 34(12)
December 20, 2013 

 
Title
A Total Synthesis of Aliskiren Starting from D-Tartrate Diester
Author
Ji Hei Kim, Soo Y. Ko*
Keywords
Aliskiren, Total synthesis, D-tartrate diester, Symmetric precursor
Abstract
A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid- cis-bis-lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.
Page
3777 - 3781
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