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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 2
BKCSDE 35(2)
February 20, 2014 

 
Title
Synthesis and Bioactivity of Quercetin Aspirinates
Author
Chenjuan Lu, Feng Huang, Zexin Li, Jinshuo Ma, Huanhuan Li, Lizhen Fang*
Keywords
Quercetin, Polyphenol, Esterification, Quercetin aspirinates, Bioactivity
Abstract
Hybrids of some natural compounds are promising to obtain new leads with good biological activities for drug discovery. Three quercetin aspirinates were synthesized by esterification of the 3-and 7-hydroxyl groups of quercetin with aspirin. Biological activities of these quercetin aspirinates were initially screened and showed better cytotoxic activities against tumor cell lines HL-60 and HepG2 and less scavenging activity against DPPH than the quercetin respectively.
Page
518 - 520
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