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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 6
BKCSDE 35(6)
June 20, 2014 

 
Title
Synthesis, Anticancer and Antioxidant Activity of Novel 2,4-Disubstituted Thiazoles
Author
Tran Nguyen Minh An, Mungara Anil Kumar, Seung Hyun Chang, Mi Yeong Kim, Jung-Ae Kim*, Kap Duk Lee*
Keywords
2,4-Disubstituted thiazole, Carbazole, α-Bromoketone, Cytotoxicity
Abstract
A new series of carbazole based 2,4-disubstituted thiazole derivatives were synthesized. All the synthesized compounds were tested for their cytotoxicity against three different cancer cell lines A549, MCF-7, and HT29. Some of these compounds showed good cytotoxicity. These compounds were also evaluated for antioxidant activity. Compounds 3a, 3b, 3d-f and 3i showed higher antioxidant activity than standard BHT.
Page
1619 - 1624
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