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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 20, Number 6
BKCSDE 20(6)
June 20, 1999 

 
Title
Stabilization of Poly(dA)[poly(dT)]2 Triplex by Anthryl and Acridine Derivatives: Effect of Side Chanis and Nitrogen Atom on the Polycyclic Aromatic Ring
Author
Gil-Jun Lee, Chang-Beom Cho, Dong-Jin Lee, Joon-Won Park, Seog K. Kim
Keywords
Abstract
The effects of anthryl derivatives and 9-aminoacridine on the thermal melting profile of a poly(dA)[poly(dT)]₂triplex were compared 9-Aminoacridine stabilizes the triplex far more effectively than anthryl derivatives. The absorption and CD and LD spectroscopic characteristics of anthryl derivatives are similar to those of 9-aminoacridine when complexed with the triplex; the N atom of acridine, which can act as a hydrogen bond acceptor, plays an important role in triplex stabilization.
Page
653 - 656
Full Text
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